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Can Mounjaro Affect Your Liver? Can It Cause Liver Damage? The Tests That Tell You the Truth

By Tharb Faisl

Many patients search online asking, “Can Mounjaro cause liver damage?” The truth is that while liver complications are rare, monitoring your Mounjaro liver health with blood tests is essential for safety. As the popularity of Mounjaro (tirzepatide) rises in London and globally, so do the questions about its safety – particularly when it comes to liver health.

Whether you’re using Mounjaro to manage type 2 diabetes or as part of a weight loss plan, it’s essential to ask:

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Can Mounjaro damage your liver? And how would you know?

At Marylebone Diagnostic Centre, we offer fast, discreet liver function blood testing in Central London to give you clarity and peace of mind.

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Can Mounjaro Cause Liver Damage?

Your liver plays a vital role in processing medications, filtering toxins, and managing metabolism. Some users of Mounjaro report elevated liver enzymes, and though rare, cases of liver stress or injury can occur – especially with long-term use or when combined with other medications or alcohol.

That’s why routine liver monitoring is key to staying safe.

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What Liver Tests Should You Do?

Our Mounjaro Safety Panel includes a comprehensive liver profile:

Test NameWhat It Measures
ALT & ASTEnzymes that indicate liver cell damage
ALP (Alkaline Phosphatase)Levels may rise with bile duct issues or liver inflammation
GGTSensitive to alcohol and medication-induced liver stress
Total BilirubinHigh levels may suggest liver dysfunction or bile blockage
Albumin & Total ProteinReflects the liver’s synthetic function

These results give a complete picture of how your liver is coping – even before you feel any symptoms.

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Symptoms of Liver Trouble to Watch For

Some signs of liver issues on Mounjaro can be subtle but shouldn’t be ignored:

  • Unusual fatigue or weakness
  • Nausea and loss of appetite
  • Yellowing of the eyes or skin (jaundice)
  • Dark urine or pale stool
  • Itchy skin
  • Pain or swelling in the upper right abdomen

Experiencing any of these? A same-day liver test at Marylebone can rule out complications early.

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Why Marylebone Diagnostic Centre?

  • Located on Baker Street, Central London – near Harley Street, Kings Cross & Mayfair
  • Fast, discreet liver function tests — same-day appointments available
  • Option to add other markers like kidney, thyroid, or GLP-1 panels
  • Results within 24 hours, plus expert guidance on next steps
Marylebone diagnostic centre main

Whether you’re proactively monitoring or managing symptoms, our team is here to support your long-term health on Mounjaro.

July 2025 Update: What New Research Says About Mounjaro & the Liver

As of July 2025, several new studies have provided more insights into how Mounjaro (tirzepatide) may impact liver health.

Mild liver enzyme rises are still the most common finding.
Recent papers in The Journal of Diabetes & Metabolism reviewed over 5,000 patients. They found that while small increases in ALT and AST can occur, serious liver injury remains extremely rare.

Fatty liver improvements in many patients.
Interestingly, some people taking Mounjaro for weight loss showed better liver ultrasound results. This is likely because weight loss itself reduces liver fat.

Who needs to be cautious?
Patients with pre-existing liver disease (like cirrhosis or hepatitis) are still advised to have regular blood tests. This ensures any subtle changes are picked up early.

At Marylebone Diagnostic Centre, we continue to monitor these trends closely. Our Liver Function and eGFR panels give you quick answers – often with same day results in London.

If you have questions or want personalised advice, we’re here to help.

For men concerned about fertility, see our guide: Mounjaro and Male Fertility in London

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FAQ: Mounjaro & Liver Health

FAQ with Drop Arrows
Can Mounjaro cause liver damage long-term?
There is no strong evidence that Mounjaro causes long-term liver damage in healthy patients. Mild enzyme changes are possible, so regular monitoring is important. At Marylebone Diagnostic Centre, we offer quick and accurate liver blood tests to track your safety.
What are the signs of Mounjaro liver problems?
Signs may include unexplained fatigue, persistent nausea, yellowing of the skin or eyes (jaundice), or dark urine. If you notice these symptoms, book a same-day liver test at MDC in Baker Street.
Which liver blood tests are best while taking Mounjaro?
The key tests are ALT, AST, ALP, and bilirubin, which form a standard Liver Function Test (LFT). At MDC, we often combine this with kidney function checks like eGFR for a complete assessment.
How often should I test my liver if I am on Mounjaro?
Most specialists recommend testing every 3–4 months while on Mounjaro. If you already have liver concerns or symptoms, more frequent monitoring may be needed.
Is Mounjaro safe if I already have liver disease?
Patients with existing liver disease should only take Mounjaro with close medical supervision. At Marylebone Diagnostic Centre, we provide baseline and follow-up tests to ensure your treatment remains safe and tailored to you.

Don’t Wait for Symptoms – Know Where You Stand

Book your Mounjaro safety test today – same day slots available

  • Central London
  • Same-day service
  • Discreet & expert-led
  • Peace of mind included

Book Now or call +44 7495 970109

Marylebone Diagnostic Centre

73 Baker Street, W1U 6RD

Read More:

FDA – Tirzepatide Prescribing Information
NHS – Liver Function Test