Price: £900
TAT: Approximately 1 Month
Sample Type: Blood
5-minute walk from Baker Street
Near Paddington & Marylebone
Same-week appointments available
Reviewed by Dr Lauren
NHS & NICE Referenced Accuracy
Thrombophilia & Blood Clotting Test London – Full Thrombotic Risk Profile
Comprehensive thrombophilia testing in London. Detect genetic and acquired clotting risks including Factor V Leiden. Book today at Marylebone Diagnostic Centre.
What Is Thrombophilia?
Thrombophilia is a condition where the blood has an increased tendency to clot. It can be inherited (genetic) or acquired due to medical or environmental factors.
Inherited vs Acquired Thrombophilia
Inherited Thrombophilia
Inherited thrombophilia is caused by genetic variations, such as Factor V Leiden or prothrombin mutations, which affect normal clotting regulation.
Acquired Thrombophilia
Acquired thrombophilia develops later in life and may be linked to:
- Autoimmune conditions
- Hormonal factors (e.g. contraceptives, pregnancy)
- Surgery, immobility, or chronic illness
Why Thrombophilia Matters
Thrombophilia may not cause symptoms until a clot forms. Early identification helps:
- Reduce the risk of serious complications
- Guide medical decisions (e.g. surgery, pregnancy, medications)
- Support long-term prevention strategies
Risk of Serious Clotting Events
Deep Vein Thrombosis
A clot usually in the leg, causing pain, swelling, and redness.
Pulmonary Embolism
A potentially life-threatening clot that travels to the lungs.
Stroke
When a clot disrupts blood flow to the brain.
Why Testing Is Important
Because thrombophilia is often silent, blood testing is the only reliable way to assess clotting risk, particularly for individuals with a personal or family history of thrombosis.
At Marylebone Diagnostic Centre, comprehensive thrombophilia testing helps identify both genetic and acquired risk factors, supporting accurate clinical assessment and prevention planning.
What Is Included in the Thrombotic Risk Profile?
Coagulation & Clotting Markers
Antithrombin III activity
Fibrinogen
Lupus Anticoagulant
Protein C Activity
Free Protein S Antigen
Prothrombin Time (PT)
Partial Thromboplastin Time (PTT)
Autoimmune Thrombosis Markers
Anticardiolipin Antibodies IgG
Anticardiolipin Antibodies IgM
Genetic Clotting Risk Markers
Factor II Mutation (Prothrombin gene)
Factor V Leiden
MTHFR Gene Mutation
Full Blood Count & Composition
Haemoglobin
Haematocrit (HCT)
Red Blood Cell Count
White Cell Count
Platelets
Red cell indices
MCH
MCHC
MCV
RDW
MPV
White Cell Differential
Neutrophils
Lymphocytes
Monocytes
Eosinophils
Basophils
Symptoms of Blood Clotting Disorders
- Leg pain/swelling
- Chest pain
- Shortness of breath
- Recurrent miscarriage
What Causes Abnormal Clotting?
- Genetics (Factor V Leiden)
- Hormones (contraceptive pill)
- Surgery / immobility
- Autoimmune conditions
Genetic Clotting Tests Explained
Factor V Leiden
Factor V Leiden is the most common inherited thrombophilia. It affects how clotting factor V is regulated, increasing the risk of abnormal blood clots.
Carriers may have a higher risk of deep vein thrombosis, especially during pregnancy, surgery, or hormone use.
Prothrombin mutation
This mutation increases prothrombin levels, leading to a higher tendency for blood to clot. It is associated with an increased risk of venous thrombosis, particularly when combined with other risk factors.
MTHFR
MTHFR variants affect folate metabolism and may influence homocysteine levels. While some studies suggest a possible link to clotting risk, the clinical significance remains debated, and testing is usually interpreted alongside other markers.
Who Should NOT Take This Test
- Individuals currently on anticoagulants (unless advised)
- During an active clotting event
- Pregnancy (interpretation may be affected)
Results Timeline Explained
Comprehensive clotting profiles require extended processing time due to the complexity of the analysis.
Genetic testing
Specialised assays
Batch processing
Total Estimated TAT: Approximately 1 Month
Blood Testing Before & After Clots
Fertility & Clotting
View Fertility Testing
Investigating the genetic link between thrombophilia and recurrent miscarriage.
Hormone Health
View Hormone Panels
Assessing hormone levels that may influence or trigger acquired clotting risks.
Inflammation Markers
View CRP Parameters
Detailed C-Reactive Protein (CRP) testing to monitor systemic inflammation.
Full Blood Count
View FBC Details
A baseline assessment of your blood composition and general health.
Frequently Asked Questions
Thrombophilia is a condition where the blood has an increased tendency to form clots. It can be inherited (genetic) or acquired due to factors such as autoimmune conditions, hormones, or inflammation. It is linked to conditions like Deep Vein Thrombosis and Pulmonary Embolism.
You may need testing if you have:
- A personal or family history of blood clots
- Recurrent or unexplained clotting events
- Recurrent miscarriage
- Clots at a young age or without clear cause
Diagnosis requires specialist blood testing, as symptoms alone are not reliable.
Factor V Leiden is the most common inherited thrombophilia. It increases the risk of abnormal clotting, especially during pregnancy, surgery, or the use of hormonal contraceptives. Many individuals remain asymptomatic, but identifying it is important for risk prevention and clinical planning.
Some clotting tests may be affected by anticoagulants such as Warfarin or Apixaban. In many cases, testing may need to be delayed or interpreted with caution. Always inform the clinic before testing to ensure accurate results and correct test selection.
Most comprehensive thrombophilia profiles take up to 4 weeks. This is because genetic analysis requires specialised laboratory processing, certain clotting markers are batch-tested for accuracy, and advanced assays require extended validation. At Marylebone Diagnostic Centre, all results follow strict quality control to meet the Marylebone High Standard.
Book Your Thrombophilia Test
£900
Same-week appointments
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Central London location
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