SS-B (La) Antibodies
SS-B (La) antibodies are autoantibodies directed against the La ribonucleoprotein antigen. They are most commonly associated with Sjögren’s syndrome and may also be detected in systemic lupus erythematosus and other connective tissue disorders. SS-B antibodies are typically identified alongside SS-A antibodies as part of a detailed autoimmune antibody profile. Detection of SS-B antibodies contributes to more precise classification of autoimmune conditions and can assist in distinguishing between primary Sjögren’s syndrome and other overlapping connective tissue diseases.
- Price: £80
- Code: SSB
- TAT: 10 Working Days
- Sample Type: Blood
Clinical Significance
SS-B antibodies are particularly associated with Sjögren’s syndrome, a chronic autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, leading to dryness of the eyes and mouth. When both SS-A and SS-B antibodies are present, the likelihood of Sjögren’s syndrome increases significantly. While SS-B antibodies may also be detected in systemic lupus erythematosus, they are less commonly found in isolation. Their presence helps refine diagnostic interpretation when patients present with overlapping autoimmune features. In pregnancy, SS-B antibodies may also carry implications similar to SS-A antibodies, although SS-A positivity is more strongly associated with neonatal lupus and congenital heart block.
Who Might Benefit From This Test?
This test may be appropriate for individuals experiencing persistent dryness of the eyes or mouth, chronic fatigue, joint pain, or other symptoms suggestive of autoimmune disease. It is commonly requested following a positive ANA test or when Sjögren’s syndrome is suspected clinically. Patients undergoing comprehensive autoimmune evaluation may benefit from combined SS-A and SS-B antibody testing to support accurate diagnosis and classification.
Sample Collection
A blood sample is obtained by a qualified healthcare professional. The procedure is straightforward and completed within minutes. Samples are analysed in accredited laboratories to ensure accurate detection of SS-B antibodies.
Understanding Your Results
A positive SS-B result supports the presence of an autoimmune connective tissue disorder when interpreted alongside clinical symptoms and other antibody findings. Negative results may reduce the likelihood of Sjögren’s syndrome but do not exclude autoimmune disease entirely. Interpretation is conducted in the context of ANA testing, inflammatory markers, and comprehensive clinical evaluation.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre offers advanced autoimmune diagnostic testing within a professional clinical environment. With a turnaround time of 10 days, this test supports accurate disease identification and appropriate specialist referral.
Book Now
Book the SS-B (La) Antibodies (SSB) test today to support thorough investigation of autoimmune connective tissue conditions.
