SS-A (Ro) Antibodies
SS-A (Ro) antibodies are autoantibodies directed against components of intracellular ribonucleoprotein complexes. They are most commonly associated with autoimmune connective tissue diseases, particularly Sjögren’s syndrome and systemic lupus erythematosus (SLE). Detection of SS-A antibodies plays an important role in diagnosing and classifying autoimmune disorders affecting multiple organ systems. These antibodies may be present even when standard antinuclear antibody (ANA) tests are negative, making specific SS-A testing valuable in patients with suggestive clinical symptoms. SS-A antibodies are also clinically significant in pregnancy due to their association with neonatal lupus and congenital heart block.
- Price: £80
- Code: SSA
- TAT: 10 Working Days
- Sample Type: Blood
Clinical Significance
SS-A antibodies are detected in a high proportion of patients with primary Sjögren’s syndrome, a condition characterised by dry eyes, dry mouth, fatigue, and systemic autoimmune features. They are also frequently present in systemic lupus erythematosus, subacute cutaneous lupus, and other overlap connective tissue disorders. In pregnant women with positive SS-A antibodies, there is a small but significant risk of neonatal lupus, which may include congenital heart block in the fetus. For this reason, identification of SS-A antibodies is particularly important in women with known autoimmune disease who are planning pregnancy or already pregnant. SS-A testing is often performed as part of an Extractable Nuclear Antigen (ENA) panel following a positive ANA result, or when autoimmune symptoms persist despite inconclusive screening tests.
Who Might Benefit From This Test?
This test may be appropriate for individuals experiencing persistent dry eyes, dry mouth, unexplained fatigue, joint pain, skin rashes, or other symptoms suggestive of autoimmune connective tissue disease. It may also be requested in patients with positive ANA results requiring further clarification. Women with known autoimmune conditions who are planning pregnancy may benefit from SS-A antibody testing to assess potential fetal risk and guide monitoring.
Sample Collection
A blood sample is collected by a trained healthcare professional in a clinical setting. The procedure is quick and minimally invasive. Samples are analysed in accredited immunology laboratories using validated techniques for precise antibody detection.
Understanding Your Results
A positive SS-A result supports the diagnosis of certain autoimmune connective tissue disorders when interpreted alongside clinical findings. However, results are not diagnostic in isolation and must be correlated with symptoms, additional antibody tests, and sometimes imaging or specialist assessment. A negative result reduces the likelihood of SS-A-associated autoimmune disease but does not entirely exclude it, particularly in early or evolving cases.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre provides comprehensive autoimmune and immunology testing within a professional and discreet environment. With a turnaround time of 10 days, this test supports accurate diagnosis, risk assessment, and timely specialist referral where appropriate.
Book Now
Book the SS-A (Ro) Antibodies (SSA) test today to support detailed investigation of autoimmune connective tissue disease.
