ss-DNA Antibody
Single-stranded DNA (ss-DNA) antibodies are autoantibodies directed against single-stranded forms of DNA. They are most commonly associated with autoimmune connective tissue diseases, particularly systemic lupus erythematosus (SLE). While anti-double stranded DNA (dsDNA) antibodies are more specific for lupus, ss-DNA antibodies may be detected in broader autoimmune activity and can contribute to the overall immunological profile in patients with suspected systemic autoimmune disorders. Detection of ss-DNA antibodies helps clinicians assess immune system dysregulation and may support evaluation of inflammatory or connective tissue disease when interpreted alongside other antibody markers.
- Price: £99
- Code: DNASS
- TAT: 10 Working Days
- Sample Type: Blood
Clinical Significance
ss-DNA antibodies may be present in systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis, and other autoimmune conditions. However, they are less specific than anti-dsDNA antibodies and therefore are not used in isolation to confirm a diagnosis of lupus. Elevated levels may reflect active immune stimulation or systemic inflammation. In some patients, antibody levels may fluctuate with disease activity, although this relationship is less clearly defined compared with anti-dsDNA testing. ss-DNA antibody testing is often performed as part of a broader autoimmune panel including ANA, anti-dsDNA, extractable nuclear antigen (ENA) antibodies, and complement levels. Together, these markers help refine diagnosis and guide clinical monitoring.
Who Might Benefit From This Test?
This test may be appropriate for individuals experiencing symptoms such as persistent fatigue, joint pain, skin rashes, photosensitivity, unexplained fevers, or other features suggestive of autoimmune connective tissue disease. It may also be requested following a positive ANA result to further characterise antibody patterns. Clinicians may include ss-DNA testing in complex autoimmune investigations where overlapping symptoms are present.
Sample Collection
A blood sample is collected by a trained healthcare professional in a clinical setting. The procedure is quick and minimally invasive. Samples are analysed in accredited immunology laboratories to detect and quantify ss-DNA antibodies.
Understanding Your Results
A positive result indicates the presence of antibodies directed against single-stranded DNA but does not confirm a specific diagnosis on its own. Interpretation depends on accompanying clinical symptoms and additional laboratory findings. Negative results reduce the likelihood of certain autoimmune conditions but do not fully exclude them. Results are carefully reviewed in conjunction with other immunological markers to determine whether further specialist referral or monitoring is required.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre provides comprehensive autoimmune and immunology testing within a professional and discreet environment. With a turnaround time of 10 days, this test supports accurate evaluation of systemic autoimmune conditions and appropriate specialist referral.
Book Now
Book the ss-DNA Antibody (DNASS) test today to support detailed investigation of autoimmune disease.
