Marylebone Parameters
Glucose-6-Phosphate Dehydrogenase (G6PD)
The Glucose-6-Phosphate Dehydrogenase (G6PD) blood test measures the activity of the G6PD enzyme in red blood cells. G6PD plays a vital role in protecting red blood cells from oxidative damage and helping them function normally. A deficiency in this enzyme can make red blood cells more vulnerable to breakdown, a process known as haemolysis. G6PD deficiency is one of the most common inherited enzyme disorders worldwide. Many people with the condition have no symptoms in everyday life, but exposure to certain medications, foods, infections, or chemicals can trigger episodes of red blood cell breakdown. Testing helps identify individuals at risk and supports safe medical decision-making.
What's included
- Glucose-6-Phosphate Dehydrogenase (G6PD)
What is G6PD and why is it important?
G6PD is an enzyme involved in protecting red blood cells from oxidative stress. It helps maintain the integrity of red blood cells by supporting the production of substances that neutralise harmful oxidative compounds.
When G6PD activity is reduced, red blood cells are less able to cope with oxidative stress. This can lead to their premature destruction, resulting in haemolytic anaemia. The condition is inherited and is more common in people of African, Mediterranean, Middle Eastern, and Asian descent.
Why might I need a G6PD test?
A G6PD test may be recommended if you have a history of unexplained anaemia, jaundice, or episodes of fatigue following illness, medication use, or certain food exposures.
The test is also commonly requested before prescribing specific medications that can trigger haemolysis in people with G6PD deficiency. In newborns and children, testing may be considered if there is unexplained jaundice or a family history of the condition.
What do the results mean?
Low G6PD activity suggests G6PD deficiency. The severity of deficiency can vary, and many individuals remain asymptomatic unless exposed to triggering factors.
Normal results indicate adequate enzyme activity. Results are interpreted alongside clinical history and, where relevant, other blood tests. Your healthcare professional will explain what your result means for you and whether any precautions or follow-up are needed.
How is the test performed?
The G6PD test is performed using a blood sample collected during a short appointment. The procedure is routine, and our clinical team will ensure you are comfortable throughout.
Do I need to prepare the test?
No special preparation or fasting is required for this test unless you have been advised otherwise.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre provides professional enzyme and haematology testing in a calm and supportive environment, with clear communication and timely results.
Our experienced clinical team ensures careful handling of samples and supports you in understanding your results and any implications for your health or treatment.
Frequently asked questions
When will I receive my results?
Should I discuss my results with a doctor?
