Can Shockwave Therapy Break Down Plaque in Peyronie’s Disease?

Can Shockwave Therapy Break Down Plaque in Peyronie’s Disease?

Shockwave therapy has been studied in men with Peyronie’s disease, and many research has reported reductions in measured plaque size.

What is the plaque in Peyronie’s disease?

Peyronie’s disease involves the development of fibrous scar tissue within the penis. Depending on its location and extent, this can contribute to penile curvature, shortening, discomfort and difficulties with sexual function.

This is important because Peyronie’s plaque is not simply a deposit that shockwaves mechanically shatter in the way shockwaves can be used for certain urinary stones.

What does the research show?

Research into extracorporeal shockwave therapy (ESWT) for Peyronie’s disease has produced mixed results.

A 2023 systematic review and meta-analysis of four randomised controlled trials found a statistically significant reduction in plaque size and improvement in pain, but did not find significant improvement in penile curvature or sexual function.

An earlier meta-analysis of randomised trials similarly found a reduction in plaque size but questioned the clinical significance because penile curvature did not significantly improve.

This distinction matters:

A change in plaque measurement does not automatically mean that the penile curvature has been corrected.

So, could shockwave still have a role?

Potentially, but the reason for treatment matters.

Shockwave therapy has been investigated for symptoms associated with Peyronie’s disease, particularly pain, but evidence does not support presenting it as a reliable method for removing plaque or straightening the penis. Current AUA guidance advises against using ESWT specifically to reduce penile curvature or plaque size.

The appropriate approach depends on factors such as the stage of Peyronie’s disease, pain, degree of curvature, erectile function, plaque characteristics and how much the condition interferes with sexual activity.

Peyronie’s assessment at MDC

At Marylebone Diagnostic Centre (MDC), men concerned about Peyronie’s disease can be directed towards appropriate urology and andrology assessment, rather than assuming that one treatment is suitable simply because a penile plaque is present.

Where specialist assessment is appropriate, MDC works with Mr Giulio Garaffa, Consultant Urological Surgeon, whose practice includes andrology, erectile dysfunction and penile conditions.

If you have noticed a new penile curve, a palpable plaque, painful erections or changes in erectile function, the MDC Men’s Health team can help guide you towards the appropriate next step.

Speak to the MDC Men’s Health Team →
Arrange a specialist urology/andrology consultation →

Can shockwave reduce Peyronie’s plaque?
Some clinical studies have reported reductions in measured plaque size after ESWT, but results are inconsistent and this does not necessarily mean the penile curvature will improve.

Does shockwave physically break the plaque apart?
It is not accurate to think of Peyronie’s shockwave treatment as mechanically smashing or dissolving scar tissue like stone fragmentation.

Can shockwave improve penile curvature?
Current controlled evidence has not demonstrated a consistent significant improvement in curvature, which is why proper assessment of the condition is important.

Why might shockwave be discussed in Peyronie’s disease?
Research has investigated ESWT particularly in relation to symptoms such as penile pain, although findings vary between studies.

Quick answers

Can shockwave therapy straighten the penis in Peyronie’s disease?

Current controlled evidence has demonstrated consistent significant improvement in penile curvature.

Can shockwave therapy break down plaque in Peyronie’s disease?

Many studies have reported reductions in measured plaque size after shockwave therapy

What symptoms might shockwave therapy help with in Peyronie’s disease?

Research has investigated shockwave therapy particularly for penile pain associated with Peyronie’s disease, and a 2023 meta-analysis found improvement in pain, although findings vary between studies.

What is Peyronie’s plaque made of?

Peyronie’s disease involves fibrous scar tissue within the penis. Depending on location and extent, this can contribute to penile curvature, shortening, discomfort and difficulties with sexual function.

Written by Mr Tharb Faisl
Writer / Scientist

Medically reviewed by Mr Giulio Garaffa
Consultant Urological Surgeon

Last medically reviewed: 13 September 2026