Male fertility genetics
IBgenSperm — Male Fertility Genetic Test
An advanced genetic investigation for male infertility. IBgenSperm examines 426 genes associated with sperm production and male fertility. Using Next Generation Sequencing (NGS), the test looks for genetic variants that may help explain why spermatogenesis, the process through which sperm cells are produced, is impaired.
- 426 genes analysed for spermatogenesis
- Uses Next Generation Sequencing (NGS)
- Helps investigate unexplained male infertility
What's included
What this test analyses.
- 426 genes associated with sperm production and spermatogenesis
Who may benefit from IBgenSperm?
The test may be considered for men with:
- Azoospermia, no sperm detected in the ejaculate
- Severe oligozoospermia, very low sperm concentration
- Asthenozoospermia, reduced sperm motility
- Oligoteratozoospermia, low sperm concentration combined with abnormal morphology
- Persistently abnormal semen analysis results
- Unexplained male infertility
- Repeated implantation failure where the underlying cause remains unclear
- Fertility problems where routine investigations have not provided an explanation
Why investigate 426 genes?
Sperm production is a complex biological process involving many different genes.
Rather than investigating only one or two possible genetic abnormalities, IBgenSperm simultaneously analyses a large panel of genes associated with spermatogenesis.
This may provide additional information about the potential biological cause of male infertility and can help clinicians determine whether further genetic counselling, fertility investigation or assisted reproductive treatment should be considered.
Male Fertility Genetics at MDC
Male fertility assessment should not always stop at a conventional semen analysis.
Where clinically appropriate, MDC can combine genetic investigation with a broader male fertility assessment including:
- Comprehensive semen analysis
- Sperm DNA fragmentation testing
- Male fertility hormone profiles
- Testosterone and reproductive hormone assessment
- Male fertility blood testing
- Ultrasound investigations where clinically indicated
- Y chromosome microdeletion testing
- Advanced male infertility genetic testing
- Urology and andrology consultation
This allows genetic results to be considered alongside the patient's wider fertility picture rather than being viewed in isolation.
Important information
Genetic screening cannot eliminate all genetic or reproductive risk. A negative carrier screening result significantly reduces the likelihood of carrying the conditions investigated but does not exclude all genetic disorders. The clinical significance of genetic findings can vary, and some results may require interpretation by an appropriately qualified clinician or genetic counsellor. Genetic testing should be considered alongside medical history, family history and other fertility investigations.
Frequently asked questions
What is IBgenSperm?
Is IBgenSperm the same as a semen analysis?
Is IBgenSperm the same as sperm DNA fragmentation testing?
Can genetic testing explain all cases of male infertility?
