Sperm Antibodies (Serum)
Sperm Antibodies (Serum) testing detects the presence of antisperm antibodies circulating in the bloodstream. These antibodies are produced when the immune system mistakenly identifies sperm cells as foreign and mounts an immune response against them. This immune reaction may interfere with sperm motility, function, and the ability to fertilise an egg, potentially contributing to infertility. Antisperm antibodies may develop following trauma, infection, surgery involving the reproductive tract, or disruption of the blood–testis barrier. In some cases, no clear cause is identified. Testing helps determine whether an immune factor may be contributing to subfertility.
- Price: £97
- Code: SAB
- TAT: 10 Working Days
- Sample Type: Blood
Clinical Significance
In men, antisperm antibodies may reduce sperm motility or impair their ability to penetrate cervical mucus and bind to the egg. In women, antisperm antibodies may interfere with sperm transport through the reproductive tract or affect fertilisation. The presence of sperm antibodies does not always result in infertility, but elevated levels may reduce the likelihood of natural conception. This test is often performed as part of a broader fertility assessment, alongside semen analysis, hormonal profiling, and imaging where appropriate. Identification of antisperm antibodies may influence management strategies, including consideration of assisted reproductive techniques such as intrauterine insemination (IUI) or in vitro fertilisation (IVF), depending on clinical circumstances.
Who Might Benefit From This Test?
This test may be appropriate for couples experiencing unexplained infertility, particularly when standard semen analysis results appear normal yet conception has not occurred. It may also be recommended following vasectomy reversal, testicular trauma, or reproductive tract infection. Clinicians may include sperm antibody testing when immune-mediated infertility is suspected or when planning assisted reproduction.
Sample Collection
A blood sample is collected by a trained healthcare professional in a clinical setting. The procedure is straightforward and completed within minutes. Samples are analysed in specialist laboratories to detect and quantify antisperm antibodies.
Understanding Your Results
A positive result indicates the presence of antisperm antibodies, though the clinical significance depends on antibody levels and associated fertility findings. A negative result suggests that immune-mediated sperm impairment is unlikely. Results are interpreted alongside semen analysis and reproductive history to guide further investigation or treatment planning.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre offers comprehensive fertility and reproductive health testing in a discreet and professional environment. With a turnaround time of 10 days, this test supports informed fertility evaluation and personalised care planning.
Book Now
Book the Sperm Antibodies (Serum) (SAB) test today to support a thorough assessment of reproductive health.
