Folate Receptor Autoantibody Test (FRAT) in London
The Only Clinic in London & Harley Street Offering FRAT Testing - £699
A specialist diagnostic test for folate transport, fertility, pregnancy health, and neurodevelopment. The Folate Receptor Autoantibody Test (FRAT) is a rare and highly specialised blood test used to detect autoantibodies that disrupt the transport of folate in the body. These autoantibodies can interfere with folate delivery to the brain, placenta, and developing embryo. Marylebone Diagnostic Centre (MDC) is the only clinic in London - including Harley Street – offering FRAT testing. Our clinical team manages the full pathway from sample collection to final reporting, ensuring accuracy, clarity, and a smooth experience for every patient.Book Now
FRAT Test for Children – Clinical Information & FAQs for Families
Learn MoreWhat Is the FRAT Test?
FRAT measures two types of folate receptor autoantibodies:
- Blocking autoantibodies - they prevent folate from binding to the folate receptor.
- Binding autoantibodies - they attach to the receptor and impair folate transport.
These antibodies may contribute to conditions such as:
- Unexplained infertility
- Recurrent miscarriage
- Pregnancy complications
- Cerebral Folate Deficiency
- Developmental or neurological symptoms in children
- Autism-related pathways
- Autoimmune-related health concerns
FRAT testing provides clarity when routine blood tests appear normal, but symptoms persist.
Why do autism researchers look at FRAT?
Multiple studies found that:
- A large proportion of children with autism have blocking or binding folate receptor autoantibodies.
- These autoantibodies reduce folate transport across the blood-brain barrier.
- Treating with folinic acid (under medical supervision) may improve certain symptoms in some children.
Who Should Consider the FRAT Test?
You may benefit from FRAT testing if you have:
- Difficulty conceiving with normal hormone tests
- Recurrent pregnancy loss
- Unexplained infertility as a couple
- A child with neurological or developmental concerns
- Suspected cerebral folate deficiency
- Low folate levels without a clear cause
- A clinician recommending advanced folate pathway testing
MDC offers FRAT testing for adults and children, with clear and supportive clinical pathways.
How the FRAT Test Works at MDC
Your sample is collected and processed by our clinical and laboratory teams at MDC.
We ensure:
- Correct sample preparation
- Secure handling
- Controlled storage conditions
- Full compliance with the Marylebone High Standard
You will receive your official FRAT report as soon as analysis is complete.
Turnaround Time
FRAT results are typically ready 8 - 12 weeks from the date of sample processing. You may receive your results sooner than the expected times.
What the FRAT Report Includes
Your FRAT report provides:
- Folate Receptor Blocking Antibody levels
- Folate Receptor Binding Antibody levels
- Interpretation of findings
- Clinical context and optional explanation with one of our clinicians
This supports decision-making for fertility care, pregnancy health, or child development.
Price for the FRAT Test at MDC
£699 - All Inclusive (Consultation not included)
Your fee includes:
- Professional blood draw
- Laboratory processing
- Secure sample management
- Final FRAT test reporting
There are no additional charges.
Symptoms & Conditions Linked to FRAT Abnormalities
FRAT testing may be relevant if you or your child experience:
- Developmental delay or behavioural symptoms
- Speech delay
- Learning differences
- Folate-related neurological symptoms
- Unexplained infertility
- Autoimmune issues
- Recurrent miscarriage
Testing can give important insight into folate metabolism and receptor function.
How to Book Your FRAT Test
You can book directly with our clinic - no referral needed.
- Phone / WhatsApp: +44 7495 970109
- Address: 73 Baker Street, London W1U 6RD
- Open: Monday–Saturday, 8:00–16:00
- 5-minute walk from Baker Street tube.
Why Choose Marylebone Diagnostic Centre?
Important Information About the Folate Receptor Antibody Test
The Folate Receptor Antibody Test (FRAT) is not a diagnostic tool for autism or any other medical condition. Results should always be considered alongside clinical history, symptoms, and a professional medical assessment. This test is designed to support clinical decision-making and must be reviewed by a qualified healthcare professional.
Frequently Asked Questions (FRAT Test)
1. What is the FRAT test used for?
The FRAT test identifies folate receptor autoantibodies that may affect fertility, pregnancy health, and neurological development.
2. Is MDC the only provider of FRAT testing in London?
Yes. Marylebone Diagnostic Centre is the only clinic in London and Harley Street offering this specialised test.
3. Do I need a GP referral?
No referral is required. You can book directly with our team.
4. How long does the test take?
The appointment takes around ten minutes. Results usually take 8–10 weeks, up to 75 days max.
5. Is the test suitable for children?
Yes. FRAT testing may support the assessment of developmental delay or suspected cerebral folate deficiency in children. A blood sample is required for the test. To help improve comfort, a topical anaesthetic cream can be applied prior to phlebotomy.
6. Do I need to fast before the test?
No fasting is needed for the FRAT test.
7. How will I receive my results?
Your results will be provided by our clinical team. You may also book a consultation to discuss your results in detail.
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Book Your FRAT Test Today
We welcome patients from across the UK and abroad for this specialist service.
Phone / WhatsApp: +44 7495 970109
Address: 73 Baker Street, London W1U 6RD
Open: Monday–Saturday, 8:00–16:00
5-minute walk from Baker Street tube.
Book Now
