What is NAD⁺ (and why is everyone talking about it?)

By Tharb Faisl

Nicotinamide Adenine Dinucleotide (NAD⁺) is a vital coenzyme present in every cell. It plays critical roles in:

• Energy metabolism – ferrying electrons in mitochondria during glycolysis and the citric acid cycle Wikipedia
• DNA repair and gene regulation – acting as a substrate for PARPs and sirtuins, enzymes tied to longevity and stress responses Wikipedia
• Cell signalling – including roles in calcium release and immune modulation Wikipedia

Sadly, NAD⁺ levels decline as we age—which has been linked to fatigue, slower repair mechanisms, brain fog, and accelerated biological ageing

The science on restoring NAD⁺

To counteract this decline, researchers are exploring two main approaches:

1. Oral precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Early research shows these molecules are safe and increase NAD⁺ in tissues, with signs of improved insulin sensitivity, muscle strength, and neurological function—though large-scale human trials are ongoing Wikipedia
2. IV infusion of NAD⁺ itself—marketed as a rapid way to replenish levels directly in the bloodstream.

What the press says

New York Magazine’s “Strategist” asked, “Do NAD+ supplements work to reverse aging, cure jet lag?” The answer: early-stage studies suggest potential, but science hasn’t yet validated dramatic anti‑aging effects Marylebone Diagnostic Centre. (We’ll mention it more in context on Page 2.)

Vogue UK 🔍 questioned if NAD⁺ infusions are “Too Good to Be True.” Experts warn the intact NAD⁺ can’t efficiently penetrate cells—while the benefits may boil down to placebo . Still, enthusiasm persists, especially among biohackers and celebrities The Times+1New York Post+1.

The benefits, hype & scientific reality

Proven and promising benefits

Early clinical studies indicate supplementing NAD⁺ precursors may:

• Boost metabolic and cardiovascular health—studies show improved lipid metabolism and heart function AHA Journal
• Enhance cognitive function—small trials in Parkinson’s and Alzheimer’s patients show improved NAD⁺ brain levels and some symptom relief Vogue
• Support muscle and endurance—NMN has been shown to enhance performance in pre‑diabetes and amateur athletes
• Promote skin health and anti‑aging—it may boost DNA repair in skin cells, diminishing UV damage

IV vs Oral

• Oral precursors (NR/NMN) are smaller molecules that can enter cells effectively, converting to NAD⁺ from within. Safety and bioavailability data are positive, though FDA hasn’t formally approved any Vogue.
• IV infusions deliver intact NAD⁺ directly, bypassing the gut—but lack robust proof to support cellular uptake and long-term benefit .

As Vogue voices: “IV is biologically unlikely to deliver NAD⁺ into cells—suggesting effects may be placebo” .

The hype machine

Hollywood and wellness culture love NAD⁺—Jennifer Aniston, Hailey Bieber, and other celebs have glowing endorsements New York Post. But most researchers urge caution, calling for more rigorous trials before declaring NAD⁺ a fountain of youth.

Marylebone Diagnostic Centre: NAD⁺ IV in London

What they offer

At 73 Baker Street, the Marylebone Diagnostic Centre run their NAD⁺ IV drip precisely:

• Clinical-grade NAD⁺ infused via IV under supervision
• Enhanced by hydration + co-factors formulated to support mitochondrial uptake Marylebone Diagnostic Centre
• Priced at around £270 per session

They position their offering as superior to oral supplements or generic NAD brands, thanks to pharmaceutical sourcing and medical oversight Marylebone Diagnostic Centre. Patient testimonies highlight dramatic boosts in mental clarity and energy.

Is it worth it?

Potential Upsides

• Fast NAD⁺ boost—ideal before big events or when recovering from fatigue
• Professional, controlled setting with same‑day booking on Baker Street
• Comfort and quality compared to generic wellness clinics NADclinicMarylebone Diagnostic Centre

Considerations

• Uncertainty if NAD⁺ enters cells at all via IV
• Placebo effects vs real biochemical impact
• High cost per treatment compared to oral options

Combining approaches

A smart NAD⁺ regimen might combine IV infusions for immediate effect with follow-up oral precursors (e.g., NR or NMN) that can sustain intracellular levels. Don’t forget lifestyle basics: balanced nutrition, exercise, quality sleep, and stress management—all vital for supporting NAD⁺ naturally Marylebone Diagnostic Centre.

Takeaway

• NAD⁺ is essential to energy production, DNA repair, and cellular health—and declines with age.
• Oral boosters like NMN/NR are well-tolerated and show promise, though large trials are pending.
• IV therapy, such as that at Marylebone Diagnostic Centre, offers rapid NAD⁺ replenishment—but the science on cellular uptake is limited.
• Informed use means being clear on costs, setting realistic expectations, and supporting NAD⁺ through lifestyle habits.

Recommended reading & sources:

• “Do NAD+ supplements work …?” — New York Magazine Strategist
• “Are Anti‑Aging NAD+ Infusions Too Good to Be True?” — Vogue UK Health+4Vogue+4The Times+4The Guardian+1Health+1
• Reviews and clinical studies on NMN/NR safety and benefits
• Marylebone Diagnostic Centre NAD⁺ IV therapy details Marylebone Diagnostic Centre