DNA Fragmentation Test
Sperm DNA Quality Analysis in London | £399 Private Test – BOOK NOW
Worried about male fertility? Book a private DNA Fragmentation Test at Marylebone Diagnostic Centre, London. Analyse sperm DNA quality to assess reproductive health. Price: £399.
Scientific Background: What is DNA Fragmentation in Sperm?
DNA fragmentation refers to breaks or damage in the genetic material within sperm cells. While a sperm may appear normal under a microscope, its DNA can still be damaged - and this can affect fertility, embryo development, and even increase the risk of miscarriage.
Why It Matters
Even in men with normal semen parameters (motility, morphology, count), high sperm DNA fragmentation may:
- Reduce chances of successful natural conception
- Lower success rates in IVF and ICSI
- Contribute to recurrent miscarriage
- Delay time to pregnancy
How is the Test Performed?
- A semen sample is collected via masturbation after 2–5 days of abstinence
- The sample is analysed using specialised assays
- Results are provided as a percentage of fragmented vs intact DNA
Understanding Your Results (Percentage of Fragmented DNA):
- <15%: Good
- 15–30%: Borderline
- >30%: High DNA fragmentation
Price: £399. Includes consultation for result explanation and next steps.
Who Should Get This Test?
This test is ideal if you:
- Have been trying to conceive without success
- Have experienced repeated IVF/ICSI failure
- Have had recurrent miscarriages with your partner
- Have a lifestyle or medical history linked to sperm damage (e.g. smoking, obesity, heat exposure, varicocele)
- Are over age 40
How to Book
Location: 73 Baker Street, London
Turnaround: 24 hours
Contact: Call +44 7495 970109 or email [email protected]
Frequently Asked Questions (FAQs)
What is a DNA Fragmentation Test for sperm?
A DNA Fragmentation Test measures the level of damage in the genetic material of sperm. Even sperm that look normal under a microscope can carry damaged DNA, which may affect fertility and embryo health.
What causes sperm DNA fragmentation?
Common causes include: Oxidative stress, smoking and alcohol, poor diet, heat exposure (e.g. laptops on lap, hot baths), Varicocele (enlarged veins in the scrotum), infections or past fever, environmental toxins, and Ageing (especially over 40).
What are normal DNA fragmentation levels?
- <15% – Low fragmentation (good)
- 15–30% – Moderate (may affect fertility)
- >30% – High (linked to poor fertility outcomes)
Can sperm with DNA fragmentation still fertilise an egg?
Yes, but the chances of successful fertilisation, implantation, and healthy embryo development may be reduced if DNA damage is high.
How is this test different from a semen analysis?
A standard semen analysis checks sperm count, motility, and shape—but not DNA quality. A DNA Fragmentation Test goes deeper by examining the actual genetic health of sperm.
Is the DNA Fragmentation Test useful before IVF or ICSI?
Absolutely. Many fertility clinics recommend it before assisted conception treatments, especially if there’s unexplained infertility or previous IVF failure.
Can lifestyle changes improve sperm DNA quality?
Yes. Improvements in: Diet (high in antioxidants), Sleep, Stress management, Exercise, and avoiding heat and toxins can significantly lower DNA fragmentation over time.
Can supplements reduce DNA fragmentation?
Yes. Antioxidant supplements like vitamin C, vitamin E, CoQ10, zinc, and selenium may help reduce oxidative stress and improve sperm DNA integrity.
How long after starting lifestyle changes should I retest?
We recommend waiting 3 months, as it takes that long for a full sperm production cycle to complete and reflect changes.
Is this test suitable for men with normal fertility?
It’s not routine for fertile men, but it’s valuable for those: Trying to conceive for 6–12+ months without success, Over age 40, Preparing for IVF/ICSI, or With history of miscarriage or lifestyle risk factors.
Is the DNA Fragmentation Test painful or invasive?
Not at all. It only requires a semen sample, collected in a private, comfortable space at our clinic on Baker Street.
How accurate is the DNA Fragmentation Test?
Very accurate. We use validated, laboratory-based assays designed to give clear, clinically useful results. It’s widely accepted by fertility specialists.
Can I take this test if I live outside London?
Yes. We can arrange courier collection of the sample if you meet certain conditions, or we can support you with local collection at our Central London clinic.
How fast are the results?
Typically, within 24 hours, sometimes sooner depending on sample processing and lab demand.
Do I need to book in advance?
Yes. Please call or use our online booking system to reserve a private appointment. We offer discreet, same-day slots where available.
