Why DNA Fragmentation Matters in Male Fertility

Conventional semen analysis (count, motility, morphology) looks at how many sperm there are and how they move or look. But DNA fragmentation tests examine whether the DNA inside sperm is intact and undamaged.


High levels of sperm DNA fragmentation (SDF) are linked to:

  • Reduced natural conception rates
  • Lower success in IUI, IVF, or ICSI
  • Higher risk of embryo arrest or miscarriage
When is testing especially useful?

In practice, DNA fragmentation testing is especially useful in cases of:

  • Unexplained infertility (normal semen parameters but no pregnancy)
  • Recurrent miscarriage (female factors ruled out)
  • Poor outcome in prior IVF/ICSI cycles
  • Lifestyle or exposure risk (smoking, toxins, heat)

MDC performs SCD testing in our in-house lab, delivering precise results you (or your fertility specialist) can use to guide decisions.

What the Test Measures & How

We use validated methods (such as TUNEL, SCSA, Comet, or SCD) to detect DNA strand breaks, nicks, or chromatin integrity issues in sperm. The test yields a DNA Fragmentation Index (DFI) or similar percentage metric.


Typical Thresholds (DFI)
  • Low / Normal: usually < 20–25%
  • Elevated: ~25–30% or higher — may suggest increased risk to fertility outcomes

Because methods and cut-offs vary by lab, interpretation always factors in the method used, your overall fertility profile, and clinical context.

Our DNA Fragmentation Service

  • Sample collection: Coordinated with your semen analysis (same session) or standalone
  • Logistics: Clinic collection or home sample (if within 45 minutes)
  • Processing: Samples processed under strict temperature, timing, and protocol controls
  • Turnaround time: 24 hours
  • Report format: Clear written report, method used, DFI value, interpretation notes
  • Referral support: We provide data for your GP or fertility specialist to act on

Price, Bundles & Preparation

Price & Add-on Options
  • DNA Fragmentation Test (standalone): £399
  • Add-on to Semen Analysis: Discount when bundled
  • Comprehensive Fertility Bundle: £674 (Semen + Hormones + DNA Frag)
How to Prepare
  • Abstain from ejaculation for 2–5 days before sample
  • Avoid fever, illness, heavy exercise, hot baths / saunas in the days before
  • No lubricants or condoms when producing the sample
  • Inform us of medications, supplements or exposures (e.g. radiation, heat, toxins)

Who Should Consider DNA Fragmentation Testing?

Consider this test if you fall into any of these categories:

  • You have normal semen analysis but no pregnancy
  • You’ve had recurrent miscarriages
  • Previous IVF/ICSI attempts resulted in failed fertilisation, poor embryo development, or failure to implant
  • You have lifestyle risks (smoking, high-heat exposure, occupational toxins)
  • You want deeper insight before embarking on assisted reproduction

Related Services & Links

Semen Analysis

The core test for male fertility, checking sperm count, motility, and morphology. Essential if you are starting a fertility investigation.

Price: £179
View Details
Male Hormone Panel

A vital blood test measuring testosterone, LH, FSH, prolactin, and SHBG. Hormonal balance is key to sperm production and overall male health.

Price: £124
Book Now
Comprehensive Fertility Package

A bundled package combining several tests (including Semen Analysis, Hormones, etc.) for a complete health overview and the best value.

Price: £674
View Package

Frequently Asked Questions (FAQs)

Does the test guarantee answers?

No. DNA fragmentation testing is a tool. It adds depth to your fertility profile, but it does not determine everything. Results must be contextualised by your clinician.

Is it painful or invasive?

No - it uses the same semen sample as standard analysis. There’s no extra discomfort.

How reliable is the test?

It depends on lab quality, sample handling, and method. That’s why we partner with accredited labs and follow strict protocols.

If I have high fragmentation, what next?

Your fertility specialist may recommend:

  • Lifestyle and antioxidant therapy (if oxidative stress suspected)
  • Sperm selection techniques (e.g. ICSI with advanced selection)
  • Use of donor sperm (in extreme cases)
  • Repeat testing after intervention
How often should I repeat it?

If you change lifestyle / receive interventions, repeating after ~3–6 months (one or two sperm cycles) is reasonable.

Does MDC treat fertility?

No - we are a diagnostic centre. Our role is to supply high-quality data (reports, lab values) to assist your doctor or fertility clinic.