Soluble Transferrin Receptor
Soluble Transferrin Receptor (sTfR) is a circulating form of the transferrin receptor, a protein involved in cellular iron uptake. Measurement of soluble transferrin receptor levels provides valuable insight into iron metabolism and erythropoiesis (red blood cell production). Unlike ferritin, which may be elevated during inflammation, soluble transferrin receptor is less affected by inflammatory states, making it particularly useful in distinguishing iron deficiency anaemia from anaemia of chronic disease. The test helps assess whether the body’s tissues are experiencing functional iron deficiency, even when standard iron markers appear inconclusive.
- Price: £88
- Code: SFR
- TAT: 8 Working Days
- Sample Type: Blood
Clinical Significance
When iron stores are depleted, cells increase expression of transferrin receptors to enhance iron uptake. As a result, soluble transferrin receptor levels rise in iron deficiency. Elevated sTfR levels therefore support the diagnosis of iron deficiency anaemia. In contrast, in anaemia of chronic disease or inflammation, ferritin levels may be normal or elevated despite reduced iron availability. In such cases, soluble transferrin receptor remains within normal range or only mildly elevated, helping clinicians differentiate between conditions. The sTfR test is especially valuable in complex clinical situations, including chronic inflammatory disorders, pregnancy, chronic kidney disease, or in patients with combined iron deficiency and chronic disease.
Who Might Benefit From This Test?
This test may be appropriate for individuals with unexplained anaemia, borderline iron studies, chronic inflammatory conditions, or symptoms such as fatigue, weakness, and reduced exercise tolerance. It may also be requested when ferritin results are difficult to interpret. Clinicians frequently use soluble transferrin receptor testing alongside ferritin, serum iron, transferrin saturation, and full blood count to obtain a comprehensive picture of iron status.
Sample Collection
A blood sample is collected by a trained healthcare professional. The procedure is quick and minimally invasive. Samples are analysed in accredited laboratories to ensure accurate quantification of soluble transferrin receptor levels.
Understanding Your Results
Elevated soluble transferrin receptor levels suggest iron deficiency and increased red blood cell production demand. Normal levels in the presence of anaemia may indicate anaemia of chronic disease rather than pure iron deficiency. Results are interpreted alongside other iron markers and clinical findings. Further evaluation may be recommended to identify underlying causes of iron imbalance, such as dietary deficiency, blood loss, or malabsorption.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Book the Soluble Transferrin Receptor (SFR) test today to support detailed evaluation of iron status and red blood cell health.
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