Sex Hormone Binding Globulin (SHBG)
Sex Hormone Binding Globulin (SHBG) is a glycoprotein produced primarily by the liver that binds to sex hormones, including testosterone and oestrogen, in the bloodstream. By regulating the proportion of hormones that are bound versus free, SHBG plays a central role in controlling hormonal bioavailability and activity at tissue level. Only unbound (free) hormones are biologically active. Therefore, SHBG measurement is essential in accurately interpreting total testosterone or oestrogen levels, particularly in cases where hormonal imbalance is suspected.
- Price: £50
- Code: SHB
- TAT: 1 - 2 Working Days
- Sample Type: Blood
Clinical Significance
Abnormal SHBG levels may influence the amount of free testosterone or oestrogen available to tissues. Elevated SHBG levels may reduce free testosterone despite normal total testosterone, potentially contributing to symptoms such as fatigue, low libido, reduced muscle mass, or menstrual irregularities. Conversely, low SHBG levels may increase free androgen availability and are often associated with insulin resistance, polycystic ovary syndrome (PCOS), obesity, or metabolic syndrome. SHBG testing is commonly performed alongside total testosterone, free testosterone, oestradiol, luteinising hormone (LH), and follicle-stimulating hormone (FSH) to provide a comprehensive assessment of endocrine function.
Who Might Benefit From This Test?
This test may be appropriate for individuals experiencing symptoms of hormonal imbalance, including low libido, fatigue, irregular menstrual cycles, infertility, or features of androgen excess such as acne or excess hair growth. It may also be requested in men with suspected testosterone deficiency, women undergoing evaluation for PCOS, or patients with metabolic conditions affecting hormone regulation.
Sample Collection
A blood sample is collected by a trained healthcare professional in a clinical setting. The procedure is quick and minimally invasive. Samples are analysed in laboratories to determine circulating SHBG levels accurately.
Understanding Your Results
Results are interpreted in conjunction with total hormone levels and clinical symptoms. Altered SHBG concentrations may explain discrepancies between total and free hormone measurements. Further endocrine evaluation may be recommended depending on findings. Interpretation considers liver function, thyroid status, metabolic health, and medication use, as these factors may influence SHBG production.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre provides comprehensive hormonal and metabolic testing within a professional and discreet environment. With a turnaround time of 1–2 days, this test supports accurate endocrine assessment and personalised care planning.
Book Now
Book the Sex Hormone Binding Globulin (SHBG) (SHB) test today to support precise evaluation of hormonal balance.
