SCL-70 Antibodies
SCL-70 antibodies, also known as anti-topoisomerase I antibodies, are autoantibodies directed against the enzyme DNA topoisomerase I. Their presence is strongly associated with systemic sclerosis (scleroderma), particularly the diffuse cutaneous subtype. Testing for SCL-70 antibodies assists in identifying autoimmune connective tissue disease and provides valuable information regarding disease classification and potential organ involvement.
- Price: £128
- Code: SCL
- TAT: 10 Working Days
- Sample Type: Blood
Clinical Significance
Systemic sclerosis is a chronic autoimmune disorder characterised by fibrosis of the skin and internal organs, vascular abnormalities, and immune activation. Anti-SCL-70 antibodies are most commonly detected in patients with diffuse systemic sclerosis and are associated with a higher risk of interstitial lung disease. The presence of these antibodies can support early diagnosis, guide prognosis assessment, and influence monitoring strategies. Although not all patients with systemic sclerosis test positive for SCL-70, a positive result carries important clinical implications. SCL-70 testing is often performed as part of an Extractable Nuclear Antigen (ENA) panel following a positive Antinuclear Antibody (ANA) test.
Who Might Benefit From This Test?
This test may be appropriate for individuals experiencing symptoms such as skin thickening, Raynaud’s phenomenon, joint stiffness, unexplained shortness of breath, or other features suggestive of connective tissue disease. It may also be requested in patients with positive ANA results to further define autoimmune antibody profiles.
Sample Collection
A blood sample is collected by a qualified healthcare professional. The procedure is straightforward and completed within minutes. Samples are analysed in accredited immunology laboratories to ensure accurate detection.
Understanding Your Results
A positive SCL-70 result supports the diagnosis of systemic sclerosis in the appropriate clinical context. However, diagnosis is based on a combination of laboratory findings, clinical features, and sometimes imaging studies. A negative result does not exclude disease but may suggest an alternative autoimmune pattern. Further rheumatological evaluation may be recommended depending on findings.
FAQs
When will I receive my results?
Results are usually available within the stated turnaround time.
Should I discuss my results with a doctor?
Yes, results should always be reviewed with a qualified healthcare professional.
Why Choose Marylebone Diagnostic Centre?
Marylebone Diagnostic Centre provides comprehensive autoimmune diagnostics in a professional and discreet environment. With a turnaround time of 10 days, this test supports accurate identification of connective tissue disorders and timely specialist referral where necessary.
Book Now
Book the SCL-70 Antibodies (SCL) test today to support detailed investigation of systemic sclerosis and autoimmune disease.
