Recurrent Miscarriage Testing
Clinical clarity for your reproductive journey. Specialized testing to identify treatable factors associated with recurrent miscarriage and support your future pregnancy planning.
Recurrent miscarriage is commonly defined as three or more consecutive pregnancy losses, although investigation may sometimes be considered after two or more miscarriages depending on individual clinical circumstances and risk factors.
Identifying possible underlying causes can help guide further clinical management and support future pregnancy planning. At Marylebone Diagnostic Centre, we offer two blood test profiles designed to investigate medical factors that may be associated with recurrent miscarriage. These profiles assess a range of autoimmune, hormonal, metabolic, and nutritional markers that may influence reproductive health and early pregnancy outcomes.
Recurrent Miscarriage Profile
Overview
This profile is designed to investigate some of the most common medical factors associated with recurrent miscarriage, including autoimmune conditions, thyroid dysfunction, metabolic health, and general haematological markers.
A key component of this profile is screening for Antiphospholipid Syndrome, an autoimmune condition associated with abnormal blood clotting and recurrent pregnancy loss. The profile also evaluates thyroid function and general health markers that may influence fertility and early pregnancy outcomes.
This targeted panel can help identify potentially treatable conditions that may affect implantation, placental development, or early pregnancy maintenance.
Testing Parameters
Antiphospholipid Antibody Screening
These tests assess for antibodies associated with Antiphospholipid Syndrome, which may increase the risk of blood clot formation and pregnancy complications.
- Lupus Anticoagulant
- Anticardiolipin Antibodies (IgG & IgM)
- Beta-2 Glycoprotein I Antibodies (IgG & IgM)
Thyroid Function Tests
Thyroid hormones play an important role in reproductive health and fetal development. Thyroid dysfunction has been associated with fertility issues and pregnancy loss.
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Thyroid Peroxidase Antibodies (TPO)
Metabolic & General Health
These tests provide an overview of metabolic health and general blood parameters.
- HbA1c
- Full Blood Count (FBC)
Comprehensive Recurrent Miscarriage Profile
Overview
The Comprehensive Recurrent Miscarriage Profile includes all tests from the standard Recurrent Miscarriage Profile, with additional markers assessing nutritional status, hormonal balance, inflammation, and iron stores.
This extended panel provides a broader assessment of factors that may influence reproductive health, implantation, and early pregnancy development.
Testing Parameters
Antiphospholipid Antibody Screening: Screening for antibodies associated with Antiphospholipid Syndrome, which may affect placental blood flow and pregnancy outcomes.
Thyroid Assessment: Evaluation of thyroid function and thyroid autoimmunity.
Metabolic & Blood Health: HbA1c and Full Blood Count (FBC).
Nutritional Markers
- Folate
- Vitamin B12
- Vitamin D
- Ferritin
Hormonal Profile
Hormonal markers that may influence ovulation and reproductive health, including screening relevant to Polycystic Ovary Syndrome (PCOS).
- Prolactin
- PCOS Profile
Inflammatory Marker
- C-Reactive Protein (CRP)
When Should You Consider Testing?
Pregnancy History
- Two or more consecutive miscarriages
- Three or more first-trimester pregnancy losses
- One or more second-trimester miscarriages
Medical Background
- Personal/family history of autoimmune disease
- Known thyroid disease or PCOS
- Planning pregnancy following previous loss
Test Preparation
- Fasting is required (8–12 hours recommended).
- Water is allowed before the test.
- Continue regular medication unless advised otherwise by your doctor.
• NICE (NG126): Ectopic pregnancy and miscarriage diagnosis.
• NICE CKS: Recurrent miscarriage assessment.
• RCHT: Antiphospholipid antibody testing recommendations.
• RCOG (No. 17): Investigation of Recurrent Miscarriage.
• Cambridge University Hospitals: NHS patient information.
